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Back pain and sciatica

Highlights

Statistics:

Overview:

Introduction

Back pain is one of the most common reasons people visit their doctor. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, 8 out of 10 people have some type of backache.

Back pain can be acute, subacute, or chronic.

Back pain can occur in any area of the back, but it is more common in the lower back, which supports most of the body's weight.

The back is highly complex, and pain may result from damage or injury to any of its various bones, nerves, muscles, ligaments, and other structures. Still, despite sophisticated techniques, which provide detailed anatomical images of the spine and other tissues, the cause of most cases of back pain remains elusive.

Vertebrae. The spine is a column of small bones, or vertebrae, that support the entire upper body. The column is grouped into three sections:


Click the icon to see an image of the spine.

Below the lumbar region is the sacrum, a shield-shaped bony structure that connects with the pelvis at the sacroiliac joints.

At the end of the sacrum are two to four tiny, partially fused vertebrae known as the coccyx, or "tail bone."


Click the icon to see an image of the sacrum.

Each vertebra is designated by using a letter and number, alllowing the doctor to determine where it is in the spine.

The Disks. Vertebrae in the spinal column are separated from each other by small cushions of cartilage known as intervertebral disks. The disks have no blood supply of their own. They rely on nearby blood vessels to keep them nourished.


Click the icon to see an image of an intervertebral disk.
Each disk is 80% water and contains two structures.

Click the icon to see an image of the nucleus pulposus.

Processes. Each vertebra in the spine has a number of bony projections called processes. The spinous and transverse processes attach to the muscles in the back and act like little levers, allowing the spine to twist or bend. The particular processes form the joints between the vertebrae themselves, meeting together and interlocking at the zygapophysial joints (more commonly known as facet, or z-joints).

Spinal Canal. Each vertebra and its processes surround and protect an arch-shaped central opening. These arches, aligned to run down the spine, form the spinal canal, which encloses the spinal cord.


Click the icon to see an image of the vertebrae and spinal cord.

Spinal Cord. The spinal cord is the central trunk of nerves that connects the brain with the rest of the body. Each nerve root passes from the spinal column to other parts of the body through small openings, bounded on one side by the disk and on the other by the facets. When the spinal cord reaches the lumbar region, it splits into four bundled strands of nerve roots called the cauda equina (meaning horsetail in Latin).


Click the icon to see an image of the cauda equina.

Symptoms and Causes

In about 85% of back pain cases, the origin of the pain is unknown, and imaging studies usually fail to determine its cause. Disk disease, spinal arthritis, and muscle spasms are the most common diagnoses. Other problems can also cause back pain, however.

Osteoarthritis occurs in joints where cartilage is damaged and then destroyed, usually as a result of aging. In reaction to this destruction, the bones associated with the joints develop abnormalities. When osteoarthritis affects the spine, it may damage the cartilage in the disks, the moving joints of the spine, or both. These changes are age-related to some degree. However, the rate at which these changes develop varies between people, and may be accelerated by trauma or excessive wear and tear. The end result of these changes is a gradual loss of spinal structure and function, as well as chronic pain, muscle spasms, and reduced mobility. Depending on which part and how much of the spine is involved, symptoms may be similar to that of a herniated disc, lumbar strain, or spinal stenosis (narrowing of the spinal canal).

A herniated disk, sometimes (incorrectly) called a slipped disk, is a common cause of severe back pain and sciatica. A disk in the lumbar area becomes herniated when it ruptures or thins out, and degenerates to the point that the gel within the disk (the nucleus pulposus) pushes outward. The damaged disk can take on many forms:

Leg pain may be worse than the back pain in cases of herniated disks. There is also some debate about how pain develops from a herniated disk and how frequently it causes low back pain. Many people have disks that bulge or protrude and do not suffer back pain. Extrusion (which is less common than the other two conditions) is highly associated with back pain, since the gel is likely to extend out far enough to press against the nerve root, most often the sciatic nerve. Extrusion is very uncommon, however, while sciatic and low-back pain are very common. But there may be other causes of low back pain.

Abnormalities in the Annular Ring. Research has also focused on tears in the annular ring -- the fibrous band that surrounds and protects the disk. The annular ring contains a dense nerve network and high levels of peptides that heighten perception of pain. Tears in the annular ring are a frequent finding in patients with degenerative disk disease. Some cases of chronic low back pain may be caused by inward growth of nerve fibers into the annular ring, which triggers pain within the intervertebral disk.

Cauda equina syndrome. Cauda equina syndrome is the impingement of the cauda equina (the four strands of nerves leading through the lowest part of the spine). The cause is usually massive extrusion of the disk material. Cauda equina syndrome is an emergency condition that can cause severe complications to bowel or bladder function. It can cause permanent incontinence if not promptly treated with surgery. Symptoms of the cauda equina syndrome include:

The Sciatic Nerve. The sciatic nerve has an extensive pathway.

Sciatica is not a diagnosis but a description of symptoms that include:

Causes of Sciatica. A herniated disk pressing on the sciatic nerve is the most common cause of sciatica, although spinal stenosis, degenerative disc disease, spondylolisthesis, or other abnormalities of vertebrae that press on the sciatic nerve can also cause pain.

Sciatic nerve
The main nerve traveling down the leg is the sciatic nerve. Pain associated with the sciatic nerve usually originates when nerve roots in the spinal cord become compressed or damaged. Symptoms can include tingling, numbness, or pain that radiates to the buttocks, legs, and feet.

Symptoms of Sciatica. Pain due to sciatica can vary widely. It may feel like a mild tingling, dull ache, or a burning sensation. In some cases, the pain is severe enough to cause immobility.

The pain most often occurs on one side. Some people have sharp pain in one part of the leg or hip and numbness in other parts. The affected leg may feel weak.

The pain often starts slowly. Sciatica pain may get worse:

Sciatica pain usually goes away within 6 weeks, unless there are serious underlying conditions. Pain that lasts longer than 30 days, or gets worse with sitting, coughing, sneezing, or straining may indicated a longer recovery.

Strain and injury to the muscles and ligaments supporting the back are the major causes of low back pain. The pain is typically more spread out in the muscles next to the spine, and may be associated with spasms in those muscles. The pain may move to the buttocks but rarely any farther down the leg.

Some cases of sciatica pain may occur when a muscle located deep in the buttocks pinches the sciatic nerve. This muscle is called the piriformis. The resulting condition is called piriformis syndrome. Piriformis syndrome usually develops after an injury. It is sometimes difficult to diagnose.

Spinal stenosis is the narrowing of the spinal canal, or narrowing of the nerve root canals where spinal nerves leave the spinal column. This condition typically develops as a person ages and the disks become drier and start to shrink. At the same time, the bones and ligaments of the spine swell or grow larger due to arthritis and chronic inflammation. However, other problems, including infection and birth defects, can sometimes cause spinal stenosis.

Most patients will report the presence of gradually worsening history of back pain over time. For others, there may be minimal history of back pain, but at some point in this process any disruption, such as a minor injury that results in disk inflammation, can cause impingement on the nerve root and trigger pain.

Patients may experience pain or numbness, which can occur in both legs, or on just one side. Other symptoms include a feeling of weakness or heaviness in the buttocks or legs. Symptoms are usually present or will worsen only when the person is standing or walking upright. Often the symptoms will ease or disappear when sitting down or leaning forward. These positions may create more space in the spinal canal, thus relieving pressure on the spinal cord or the spinal nerves. Patients with spinal stenosis are not usually able to walk for long periods of time. They may be able to ride an exercise bike.

Spondylolisthesis occurs when one of the lumbar vertebrae slips over another, or over the sacrum.

In children, spondylolisthesis usually occurs between the fifth bone in the lower back (lumbar vertebra) and the first bone in the sacrum area. It is often due to a birth defect in that area of the spine. In adults, the most common cause is degenerative disease (such as arthritis). The slip usually occurs between the fourth and fifth lumbar vertebrae. It is more common in adults over 65 and women.

Other causes of spondylolisthesis include stress fractures (commonly seen in gymnasts) and traumatic fractures. Spondylolisthesis may occasionally be associated with bone diseases.

Spondylolisthesis may vary from mild to severe. It can produce increased lordosis (swayback), but in later stages may result in kyphosis (roundback) as the upper spine falls off the lower spine.

Symptoms may include:

Pain generally occurs with activity and is better with rest. Neurological damage (leg weakness or changes in sensation) may result from pressure on nerve roots, and may cause pain radiating down the legs.

Inflammatory disorders and arthritis syndromes can produce inflammation in the spine.

Ankylosing spondylitis is a chronic inflammation of the spine that may gradually result in a fusion of vertebrae. Symptoms include a slow development of back discomfort, with pain lasting for more than 3 months. The back is usually stiff in the morning; pain improves with exercise. In severe cases, the patient must continually stoop over. It can be quite mild, however, and it rarely affects a person's ability to work. It occurs mostly in young Caucasians in their mid-20s. The disease is more common in men, but about 30% of the cases are in women. Researchers believe that in most cases the cause is hereditary.

About 20% of people with inflammatory bowel disease and about 20% of people with psoriasis develop a similar form of arthritis involving the spine. There are multiple treatments for this potentially disabling disease, including various immune suppressant medications. Etanercept (Enbrel) and infliximab (Remicade), anti-inflammatory agents known as TNF-blockers, are proving to be beneficial.

Osteoporosis is a disease of the skeleton in which the amount of calcium present in the bones slowly decreases to the point where the bones become fragile and prone to fractures. It usually does not cause pain unless the vertebrae collapse suddenly, in which case the pain is often severe. More than one vertebra may be affected.

In a compression fracture of the vertebrae, the bone tissue of the vertebra collapses. More than one vertebra may collapse as a result. When the fracture is the result of osteoporosis, the vertebrae in the thoracic (chest) and lower spine are usually affected, and symptoms may be worse with walking.

With multiple fractures, kyphosis (a forward hump-like curvature of the spine) may result. In addition, compression fractures are often responsible for loss of height. Pressure on the spinal cord may also occur, producing symptoms of numbness, tingling, or weakness. Symptoms depend upon the area of the back that is affected; however, most fractures are stable and do not produce neurological symptoms. [For more information, see In-Depth Report #18: Osteoporosis.]

Several serious conditions can also cause back pain. Often, these symptoms develop over a short period of time, become more severe, and may have other findings that go along with them. Some of these conditions include:

Any abnormality in joints, vertebrae, or nerve roots can cause back pain, including:

Risk Factors

In most known cases, pain begins with an injury, after lifting a heavy object, or after making a sudden movement. Not all people have back pain after such injuries, however. In the majority of back pain cases, the causes are unknown.

Intervertebral disks begin deteriorating and growing thinner by age 30. One-third of adults over 20 show signs of herniated disks (although only 3% of these disks cause symptoms). As people continue to age and the disks lose moisture and shrink, the risk for spinal stenosis increases. The incidence of low back pain and sciatica increases in women at the time of menopause as they lose bone density. In older adults, osteoporosis and osteoarthritis are also common. However, the risk for low back pain does not mount steadily with increasing age, which suggests that at a certain point, the conditions causing low back pain plateau.

Jobs that involve lifting, bending, and twisting into awkward positions, as well as those that cause whole-body vibration (such as long-distance truck driving), place workers at particular risk for low back pain. The longer a person continues such work, the higher their risk. Some workers wear back support belts, but evidence strongly suggests that they are useful only for people who currently have low back pain. The belts offer little added support for the back and do not prevent back injuries.

A number of companies are developing programs to protect against back injuries. However, studies have been mixed on the outcome of company interventions. Employers and workers should make every effort to create a safe working environment. Office workers should have chairs, desks, and equipment that support the back or help maintain good posture.

Low back pain accounts for significant losses in workdays and dollars. According to the Bureau of Labor Statistics, back pain was responsible for 62% of cases of people missing work due to pain involving the upper body. A 2004 study analyzed health care expenses in the United States. The analysis found back pain cost over $90 billion, of which $26 billion was spent directly on treating the back pain. According to the study, the amount of money spent on health care by people with back pain was 1.6 times higher than the health care expenses of people without back pain.

Osteoporosis
Osteoporosis is a condition characterized by progressive loss of bone density, thinning of bone tissue, and increased vulnerability to fractures. Osteoporosis may result from disease, dietary or hormonal deficiency, or advanced age. Regular exercise and vitamin and mineral supplements can reduce and even reverse loss of bone density.

Persistent low back pain in children is more likely to have a serious cause that requires treatment than back pain in adults.

Stress fractures (spondylolysis) in the spine are a common cause of back pain in young athletes. Sometimes a fracture may not show up for a week or two after an injury. Spondylolysis can cause spondylolisthesis, a condition in which the spine becomes unstable and the vertebrae slip over each other.

Hyperlordosis is an inborn exaggerated inward curve in the lumbar area. Scoliosis, an abnormal curvature of the spine in children, does not usually cause back pain.

Juvenile chronic arthropathy is an inherited form of arthritis. It can cause pain in the sacrum and hip joints of children and young people. It used to be grouped under juvenile rheumatoid arthritis, but is now defined as a separate problem.

Injuries can also cause back pain in children.

Pregnant women are prone to back pain due to a shifting of abdominal organs, the forward redistribution of body weight, and the loosening of ligaments in the pelvic area as the body prepares for delivery. Tall women are at higher risk than short women. Although some earlier research had suggested that the use of epidurals for pain relief during labor could lead to chronic back pain, studies in 2002 reported no increased risk.

Psychological factors are known to play a strong influential role in three phases of low back pain:

Studies also suggest that patients who reported prolonged emotional distress have less favorable outcomes after back surgeries. It should be strongly noted that the presence of psychological factors in no way diminishes the reality of the pain and its disabling effects. Recognizing this presence as a strong player in many cases of low back pain, however, can help determine the full range of treatment options.

Diagnosis

Although most episodes of new back pain, as well as exacerbations of chronic back pain, clear up or return to a previous level of discomfort, a medical history and a brief physical examination is always necessary. Depending on the severity of the symptoms, how long they have been present, and any associated medical problems, history and physical exam alone may or may not be sufficient.

The goal is to classify patients into one of three categories

A medical history and physical examination can usually clarify the classification.

The patient should be able to describe the back pain and its history in the following manner:

A patient should report any serious health problems, symptoms, and concerns that may raise a red flag for a more serious condition. These include:

The main goal of a physical exam is to try and determine the source of the pain and the limits of movement.

Imaging tests used to evaluate back pain range from a simple x-ray to a CT scan or MRI of the spine. Depending on medical diagnoses that are identified by the history, the patient may need such tests as a Dual energy X-ray absorptiometry (DEXA) scan for osteoporosis or a nuclear scan for suspected arthritis, cancer, or infection.

Because most patients with back pain are on the mend or completely recovered within 6 weeks, imaging techniques such as x-rays or scans are rarely recommended in the first month unless the health care provider suspects a tumor, fracture, infection, cauda equina syndrome, or progressive neurological disease.

Even when symptoms last longer, unless a potentially serious diagnosis is suspected, MRI or CT scans can often be delayed until the time when surgery or epidural steroid injections come into consideration as treatment options.

X-Rays. Many patients with acute and uncomplicated low back pain believe that plain x-rays of the spinal column are important in a diagnosis. However, they are not very helpful in most patients with nonspecific back pain.

Patients who have the following symptoms or experience certain events may need more sophisticated imaging studies:

Magnetic Resonance Imaging (MRI). Magnetic resonance imaging (MRI) can provide very well-defined images of soft tissue and bone. It is not painful, but some people may feel claustrophobic in scanners that are fully enclosed. MRIs can detect annular tears, or disk fragments, and non-spinal causes of back pain, including infection and cancer. Some medical evidence suggests that relying on MRI images of disk abnormalities to determine treatment has resulted in many unnecessary surgeries. At least 40% of all adults have bulging or protruding vertebral disks, and most have no back pain. The degree of disk abnormalities revealed by MRIs often have very little to do with the severity of the pain or the need for surgery. Disk abnormalities in people who have back pain may simply be a coincidence rather than an indication for treatment.


Click the icon to see an image of a MRI machine.
CT scan
CT stands for computerized tomography. In this procedure, a thin x-ray beam is rotated around the area of the body to be visualized. Using very complicated mathematical processes called algorithms the computer is able to generate a 3-D image of a section through the body. CT scans are very detailed and provide excellent information for the doctor.

Bone Scintigraphy and SPECT Imaging. In rare cases, doctors may use bone scintigraphy (bone scanning) to determine abnormalities in the bones. The technique may be useful for early detection of spinal fractures, cancer that has spread to the bone, or certain inflammatory arthritic conditions. During this exam, a small amount of radioactive material is injected into a vein. It circulates through the body, and is absorbed by the bones. The bones can then be seen using x-rays or single photon emission computed tomography (SPECT).

An x-ray myelogram is an x-ray of the spine that requires a spinal injection of a special dye and the need to lie still for several hours to avoid a very painful headache. It has value only for select patients with pain on moving and standing. It has largely been replaced by CT and MRI scans.

Tests that analyze the electric waveforms of nerves and muscles may be useful for detecting nerve abnormalities that may be causing back pain, and identifying possible injuries. They are also useful to determine if any abnormal structural findings on an MRI or other imaging tests have real significance as a cause of back pain. It should be noted that any nerve injuries that affect these tests may not be present for 2 - 4 weeks after symptoms begin.

Nerve conduction studies and electromyography are the electrodiagnostic tests most commonly performed. These tests are not used often in the evaluation and management of patients with low back pain.

Diskography is an x-ray of the disk. Since many people have evidence of disk degeneration on their MRI scans, it is not always easy to tell if the finding on this MRI scan explains pain the patient may be experiencing. Diskography is a test that is used to help determine whether an abnormal disk seen on MRI explains someone's pain. When performed, it is generally reserved for patients who did not experience relief from other therapies, including surgery. This procedure requires injections into disks suspected of being the source of pain and disks nearby. It can be painful. There is controversy among physicians who take care of the spine regarding the usefulness of diskography for making decisions about care, particularly surgery

Blood and urine samples may be used to test for infections, arthritis, or other conditions.

Injecting a drug that blocks pain into the nerves in the back helps locate the level in the spine where problems occur.

A procedure called a facet block is also useful in locating areas of specific damage.

Medications

Patients should understand that most people who have sudden low back pain, even with sciatica, have a high likelihood of substantial improvement over the first month.

The most commonly prescribed medications for the treatment of back pain are nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs block prostaglandins, substances that dilate blood vessels and cause inflammation and pain. Evidence suggests that short-term use of NSAIDs brings effective relief in patients with acute back pain. The benefits of NSAIDs for chronic back pain are less certain.

There are dozens of available NSAIDs:

In April 2005, the Food and Drug Administration (FDA) asked drug manufacturers of prescription NSAIDs to include with their products the same warning label used for the COX-2 inhibitor celecoxib (Celebrex). This "black box" warning, the FDA's strongest, emphasizes the increased risks for cardiovascular events (heart-related problems) and gastrointestinal (digestive tract) bleeding associated with the use of these drugs. The FDA also requested manufacturers of OTC NSAIDs to be more specific in their labels concerning potential cardiovascular and gastrointestinal risks. Due to its proven heart benefits, aspirin was excluded from these labeling revisions. In December 2006, the FDA proposed even stronger labeling changes to highlight the potential of these drugs to cause liver damage, as well as risks of alcohol and drug interactions with NSAIDs.

Long-term, regular use of NSAIDs can increase the risk for heart attack, especially for people who have a heart condition. Long-term use of NSAIDs is also the second most common cause of ulcers and gastrointestinal bleeding. To reduce the risks associated with NSAIDs, take the lowest dose possible for pain relief.

Other possible side effects of NSAIDs may include:

Long-term use of NSAIDs is the second most common cause of ulcers. Ulcers caused by NSAIDs are more likely to bleed than those caused by the bacteria Helicobacter pylori.

NSAID-related bleeding and stomach problems may be responsible for 107,000 hospital admissions and 16,500 deaths each year. Those at high risk for bleeding include people over age 60, anyone with a history of ulcers or gastrointestinal bleeding, patients with serious heart conditions, people who abuse alcohol, and those who take medications such as anticoagulants (blood thinners) and corticosteroids.

Proton-pump inhibitor (PPI) drugs may help prevent and heal ulcers caused by NSAIDs. PPIs include omeprazole (Prilosec), esomeprazole (Nexium), and lansoprazole (Prevacid).

COX-2 Inhibitors (Coxibs). Coxibs inhibit an inflammation-promoting enzyme called COX-2. This drug class was initially thought to provide benefits equal to NSAIDs but cause less gastrointestinal distress. However, following numerous reports of heart problems, skin rashes, and other adverse effects, the FDA re-evaluated the risks and benefits of this drug class. This lead to the removal of rofecoxib (Vioxx) and valdecoxib (Bextra) from the United States market. Celecoxib (Celebrex) is still available, but patients should ask their doctor whether the drug is appropriate and safe for them. In December 2006, the FDA approved celecoxib for the relief of symptoms of juvenile rheumatoid arthritis in patients ages 2 years and older.

Stomach disease or trauma
An ulcer is a crater-like lesion on the skin or mucous membrane that is caused by an inflammatory, infectious, or cancerous condition. To avoid irritating an ulcer, stop smoking and try to eliminate certain substances from your diet, including caffeine and alcohol. Prescription medicines are available to suppress the acid in the stomach that causes erosion of the stomach lining. Endoscopic therapy can be used to stop ulcer-related bleeding.

Tramadol (Ultram) is a pain reliever that has been used as an alternative to opioids. While the drug has opioid-like properties, it is not as addictive. (Dependence and abuse have been reported, however.) It can cause nausea, but does not cause the severe gastrointestinal problems that NSAIDs can. Some patients who take tramadol experience severe itching. A combination of tramadol and acetaminophen (Ultracet) is now available. It provides more rapid pain relief than tramadol alone.

Narcotics are pain-relievers that act on the central nervous system. They are the most powerful medications available for the management of pain.

There are two types of narcotics:

Opioids are effective for short-term relief of back pain. Using them for longer than 16 weeks to treat low back pain has not been well studied and may increase the risk of abuse, if a health care provdier does not manage usage well.

Newer ways to deliver pain medicine have been developed. A skin patch containing an opioid called transdermal fentanyl (Duragesic) may relieve chronic back pain more effectively than oral opioids.

Common side effects of opioids include anxiety, constipation, nausea, vomiting, dizziness, drowsiness, paranoia, urinary retention, restlessness, and labored or slow breathing. Addiction is a risk, although less than is commonly believed when these medications are used for pain relief. In fact, when prescribed properly, use of opioids for chronic pain can be safer in some cases than on-going use of NSAIDs. Unfortunately, opioid abuse among young people is a major concern. Unless the pain is very severe, experts advise against routinely prescribing opioids.

Injections of corticosteroids (commonly called steroids) are sometimes used to treat low back pain caused by nerve impingement. The injection is placed into the epidural space, just inside the outer membrane covering the spine.

The injection is directed as close to the location of the affected nerve as possible. Corticosteroids reduce inflammation.

Studies that measure the benefits of steroid injections on sciatica or low back pain are conflicting.

No high quality studies have shown that these injections provide long-term benefit for most patients, compared to more conservative treatments. However, reasonable evidence shows that patients receive short-term pain relief, generally over a 1 - 2 month period, from these injections.

Serious and painful side effects, including meningitis and inflammation, are possible. However, such risks are very low.

Epidural steroid injections for spinal stenosis may provide short-term relief of pain but generally do not improve the patient's daily functioning, nor do they help patients avoid surgery.

Researchers are investigating whether injections of botulinum toxin (Botox) in the lower back can safely and effectively relieve pain. Botox is commonly used to smooth out wrinkles. Very small amounts of Botox temporarily paralyze muscle tissue. Some studies have suggested that Botox may be very helpful in relieving chronic low back pain and sciatica caused by piriformis syndrome.

Some studies show that antidepressants may lessen the severity of pain in some patients, although they have little effect on daily functioning. Antidepressants called tricyclics may be effective painkillers in non-depressed people with chronic back pain. Such antidepressants include amitriptyline (Elavil, Endep), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), amoxapine (Asendin), nortriptyline (Pamelor, Aventyl), and maprotiline (Ludiomil).

Tricyclics can have severe side effects. Nonetheless, experts believe there is a useful role for these drugs that warrants further investigation.

A recent review of existing studies found no clear evidence that antidepressants help people with chronic low back pain. However, the reviewers noted that antidepressants help in other cases of chronic pain and that additional, larger studies are needed to clarify their effect on chronic low back pain.

A combination of nonsteroidal anti-inflammatory drugs and muscle relaxants -- such as cyclobenzaprine (Flexeril), diazepam (Valium), carisoprodol (Soma), or methocarbamol (Robaxin) -- are sometimes used for patients with acute low back pain. Evidence has shown that they can help relieve non-specific low back pain, but some experts warn that these drugs should be used cautiously, since they target the brain, not the muscles. Patients who take muscle relaxants may experience a number of central nervous system side effects, such as drowsiness. The muscle relaxant Soma can be addictive and does little more than induce sleep.

Generally, manufacturers of herbal remedies and dietary supplements do not need FDA approval to sell their products. Just like a drug, herbs and supplements can affect the body's chemistry, and therefore have the potential to produce side effects that may be harmful. There have been a number of reported cases of serious and even lethal side effects from herbal products. Always check with your doctor before using any herbal remedies or dietary supplements.

Most herbal remedies used for back pain are said to have both pain-relieving and anti-inflammatory effects. A few have been found to have some benefit when compared to placebo or sugar pill. However, none of these have been compared to other standard treatments.

White willow bark, bromelain, and Boswellia have blood-thinning properties and can interfere with anticoagulant medications, such as warfarin (Coumadin).

Other Treatments

A number of complementary and alternative treatments are used to relieve back pain. Complementary means it is used together with conventional medicine. Alternative means it is done in place of conventional medicine.

Acupuncture is now a common alternative treatment for certain kinds of pain. It involves inserting small needles or exerting pressure on certain "energy" points in the body. When the pins have been placed successfully, the patient is supposed to experience a sensation that brings a feeling of fullness, numbness, tingling, and warmth with some soreness around the acupuncture point. Unfortunately, rigorous studies of acupuncture are difficult to perform, and most evidence on its benefits is weak. In any case, it may be specifically helpful for certain patients with back pain, such as pregnant women, who must avoid medications. Anyone who undergoes acupuncture should be sure it is performed in a reputable location by experienced practitioners who use sterilized equipment.

Acupuncture has not shown any benefits for acute low back pain in most patients, but may provide some help for patients with chronic low back pain.

According to a study in the British Medical Journal, acupuncture may provide longer-lasting pain relief than physical therapy. In the study, 129 people received either 6 acupuncture treatments or 6 physical therapy sessions. The study authors cautioned that the benefit of acupuncture greatly depended on the health care provider's experience. Another study, published in the Archives of Internal Medicine, reported that acupuncture worked better than no treatment at all.


Click the icon to see an image of acupuncture.

Many well-conducted studies have shown that massage therapy can benefit patients with chronic or acute back pain, especially when combined with exercise and patient education.

Some studies report that a course of cognitive-behavioral therapy helps reduce chronic back pain, or at least enhances the patient's ability to deal with it. The primary goal of this form of therapy in such cases is to change the distorted perceptions that patients have of themselves, and change their approach to pain. Patients use specific tasks and self-observations to help them change their thinking. They gradually shift their perception of helplessness against the pain that dominates their lives into the perception that pain is only one negative among many positives and, to a degree, a manageable experience. In one study, therapists also taught relaxation techniques and methods to improve posture. The sessions lasted for 2.5 hours each week for 12 weeks. More research is needed to assess the benefits of this therapy.

Chiropractors typically perform spinal manipulations, but so do osteopathic doctors.

Spinal Manipulation for Uncomplicated Acute Low Back Pain. Spinal manipulation may be useful for acute back pain that persists beyond 2 - 3 weeks. There are a number of variations, but one example of a spinal manipulation technique is the following:

There is evidence of benefit for spinal manipulation treatment of subacute pain and exacerbations of chronic pain. Ongoing or maintenance spinal manipulation has not been proven to alter the course of chronic back pain.

Mild and temporary side effects from spinal manipulation are common. The potential for serious adverse effects from low back manipulations is low. It should be strongly noted, however, that serious complications (including stroke or spinal cord or neck injury) have been reported with manipulations of the neck. Although little research has been done on such complications, an English survey indicated that they are more frequent than commonly thought.

Some chiropractors may take a lot of x-rays, particularly those of the full spine, which may have long-term harmful consequences. Patients should also be aware that some chiropractors use alternative treatments that have not been proven or rigorously studied. All patients should require objective evidence on the benefits of their treatments.

Vertebral Axial Decompression. Vertebral axial decompression (VAX-D) may reduce pain and improve function in patients with chronic low back pain, including sciatic pain that radiates down the leg. The patient lies face down on a special table, clutching hand grips and wearing a pelvic harness. The traction-like action alternately stretches and relaxes the spine over 1-minute intervals. Each session lasts about 30 minutes. Ten to 20 sessions on successive days are often required. The procedure is thought to alleviate pain and enhance healing by relieving pressure within the disks, promoting the in-flow of oxygen, fluids, and nutrients to the spinal column. Some evidence supports its benefits, with reported success rates of around 70%. Because it is considered experimental, it is not yet covered by most insurers. More studies are needed to confirm its possible benefits.

Percutaneous Neuromodulation Therapy. A technique called percutaneous neuromodulation therapy (PNT) uses a small device that delivers electrical stimulation to deep tissues and nerve pathways near the spine.

Electrical Nerve Stimulation. Transcutaneous electrical nerve stimulation (TENS) uses low-level electrical pulses to suppress back pain. A variant of this procedure, percutaneous electrical nerve stimulation (PENS), applies these pulses through a small needle to acupuncture points. When tested in high-quality studies, electrical nerve stimulation has not been found to provide much help.

Exercise and Physical Therapy

Physical therapy with a trained professional may be useful if pain has not improved after 3 - 4 weeks. It is important for any person who has chronic low back pain to have an exercise program. Professionals who understand the limitations and special needs of back pain, and can address individual health conditions, should guide this program. One study indicated that patients who planned their own exercise program did worse than those in physical therapy or doctor-directed programs.

Physical therapy typically includes the following:

Incorrect movements or long-term high-impact exercise is often a cause of back pain in the first place. People vulnerable to back pain should avoid activities that put undue stress on the lower back or require sudden twisting movements, such as football, golf, ballet, and weight lifting.

Exercises performed after a simple diskectomy do not seem to provide much added benefit over time.

Specific and regular exercise under the guidance of a trained professional is important for reducing pain and improving function, although patients often find it difficult to maintain therapy.

Exercise does not help acute back pain. In fact, overexertion may cause further harm. Beginning after 4 - 8 weeks of pain, however, a rehabilitation program may benefit the patient.

An incremental aerobic exercise program (such as walking, stationary biking, and swimming) may begin within 2 weeks of symptoms. Jogging is usually not recommended, at least not until the pain is gone and muscles are stronger.

Patients should avoid exercises that put the lower back under pressure until the back muscles are well toned. Such exercises include leg lifts done in a facedown position, straight leg sit-ups, and leg curls using exercise equipment.

In all cases, patients should never force themselves to exercise if, by doing so, the pain increases.

Exercise plays a very beneficial role in chronic back pain. Repetition is the key to increasing flexibility, building endurance, and strengthening the specific muscles needed to support and neutralize the spine. Exercise should be considered as part of a broader program to return to normal home, work, and social activities. In this way, the positive benefits of exercise not only affect strength and flexibility but also alter and improve patients' attitudes toward their disability and pain. Exercise may also be effective when combined with a psychological and motivational program, such as cognitive-behavioral therapy.

There are different types of back pain exercises. Stretching exercises work best for reducing pain, while strengthening exercises are best for improving function.

Exercises for back pain include:

Perform the following exercises at least three times a week:

Partial Sit-ups. Partial sit-ups or crunches strengthen the abdominal muscles.

Pelvic Tilt. The pelvic tilt alleviates tight or fatigued lower back muscles.

Over time increase this exercise until it is held for 5 seconds. Then, extend the legs a little more so that the feet are further away from the body and try it again.

Stretching Lower-Back Muscles. The following are three exercises for stretching the lower back:

Note: No one with low back pain should perform exercises that require bending over right after getting up in the morning. At that time, the disks are more fluid-filled and more vulnerable to pressure from this movement.

Surgery and Invasive Procedures

The health care provider should give patients solid information on the expected course of their low back pain and self-care options before discussing surgery. Patients should ask their health care provider about evidence favoring surgery or other (nonsurgical) treatments in their particular case. They should also ask about the long-term outcome of the recommended treatment. Would the improvements last and, if so, for how long? Another consideration when surgery is an option is the overall safety of the recommended procedure, weighed against its potential short-term benefits and its benefits in the long run.

Patients should always try all possible non-surgical treatments before opting for surgery. The most common reasons for surgery for low back pain are sciatica and spinal stenosis. Some experts believe that fewer than 1% of back pain patients need aggressive medical or surgical treatments.

Nevertheless, when it is appropriate, surgery can provide great relief. Many approaches and procedures are available or being investigated. However, there have been few well-conducted studies to determine if any type of back pain surgery works better than others, or if a single procedure is better than no surgery at all.

People who are obese and have low back pain may benefit from surgical weight loss surgery. A study in the journal Obesity Surgery found that bariatric (stomach stapling) surgery significantly improves the degree of disability in morbidly obese patients who have low back pain. Before having any surgery, it is extremely important that the patient is sure the surgeon has had significant experience with the procedure.

It should be noted that surgery does not always improve outcome and, in some cases, can even make it worse. Surgery can be an extremely effective approach, however, for certain patients whose severe back pain does not respond to conservative measures.

Diskectomy is the surgical removal of the diseased disk. The procedure relieves pressure on the spine. It has been performed for 40 years, and increasingly less invasive techniques developed over time. However, few studies have been conducted to determine the procedure's real effectiveness. In appropriate candidates it provides faster immediate relief than medical treatment, but long-term benefits (over 5 years) are uncertain. A number of minimally invasive variations are now available.

Herniated disk repair
When the soft, gelatinous central portion of an intervertebral disk is forced through a weakened part of a disk, it is called a slipped disk. Most slipped disks (herniated disks) take place in the lumbar area of the spine. Slipped disks are one of the most common causes of lower back pain. The mainstay of treatment is an initial period of rest with pain and anti-inflammatory medications followed by physical therapy. If pain and symptoms persist, surgery to remove the herniated portion of the intervertebral disk may be needed.

Microdiskectomy. Microdiskectomy is the current standard procedure. It is performed through a small incision (1 to 1-1/2 inch). The back muscles are lifted and moved away from the spine. After identifying and moving the nerve root, the surgeon removes the injured disk tissue under it. The procedure does not change any of the structural supports of the spine, including joints, ligaments, and muscles.

Other, less invasive procedures that are available include:

It is not clear yet if any of these less-invasive procedures are as effective as the standard microdiskectomy.

Complications and Outlook. Many patients still have back pain after diskectomy, which delays discharge from the hospital. Narcotics are usually needed for pain relief. Adding an injected NSAID may speed resolution of pain.

Scar tissue is a significant problem, since it can cause persistent low back pain afterward. Anti-scarring agents or certain devices may help reduce surgical scars and thereby postoperative pain. Other complications of spinal surgery can include nerve and muscle damage, infection, and the need for another operation.

Patients now often remain in bed only 3 - 4 days after disk surgery. It may take 4 - 6 weeks for full recovery, however. Gentle exercise may be recommended at first. Starting intensive exercise 4 - 6 weeks after a first-time disk surgery appears to be very helpful for speeding up recovery.

Operations that remove a vertebra (laminectomy) or shave off part of one (laminotomy) may be used in certain cases of spinal stenosis or spondylolisthesis to decompress the nerve. They may also be used to remove benign tumors on the spine.

Lumbar spinal surgery - series

Click the icon to see an illustrated series detailing lumbar spinal surgery.

Although this procedure often brings immediate relief from pain, there are small risks to the operation, and it is not always successful. Some recurrence of back pain and sciatica occurs in half to two-thirds of postoperative patients. Minimally invasive variations are under investigation. For spinal stenosis, the traditional approach is a laminectomy and partial removal of the facet joint. There is controversy whether performing a fusion procedure along with these procedures is needed. Only a few randomized trials have compared this procedure with nonoperative treatment. Their results suggest that surgical treatment is better, at least over the first 2 years after surgery.

In cases where abnormal vertebrae position or movement, such as spinal stenosis or spondylolisthesis, is responsible for severe and chronic back pain, surgeons may fuse vertebrae together. Fusion uses a bone graft or some other device to join the vertebrae together. In a 2001 study of patients with severe long-term back pain, 33% of patients who had spinal fusion had less back pain after 2 years, compared to 7% who received conservative treatment with physical therapy. Pain improved most in the 6 months following surgery. However, a 2005 clinical trial found that spinal fusion surgery worked no better than intensive rehabilitation in reducing disability. The intensive rehabilitation program included both physical and cognitive-behavioral therapy.

Many spinal fusion surgeries use a tiny hollow metal cage, which is implanted into the disk space. Bone is then removed from the patient's hip and packed inside the cage. Over time the bone grows through the holes and around the device, fusing the vertebrae. Alternatively, rather than performing a bone graft, the cage is filled with a sponge-like material containing a genetically-engineered protein called InFuse (rhBMP-2) that promotes bone to grow.

Spinal fusion - series

Click the icon to see an illustrated series detailing spinal fusion.

There are currently a number of video-assisted fusion techniques. These new techniques are less invasive than standard "open" surgical approaches, which use wide incisions. To date, however, the newer procedures have higher complication rates than the open approaches, and some medical centers have abandoned them.

Percutaneous Vertebroplasty. Percutaneous vertebroplasty involves the injection of a cement-like bone substitute into vertebrae with compression fractures. It is done under endoscopic and x-ray guidance. The technique is proving useful for stabilizing the spine and relieving pain in patients with spinal compression fractures due to osteoporosis or cancer. A Mayo Clinic study found that patients who have the procedure have less back pain during rest and activity. A survey of records from more than 100 vertebroplasty patients revealed that most patients are more functional than before the procedure, and the benefits lasted for up to a year.

Warning: The Food and Drug Administration (FDA) has warned consumers that polymethylmethacrylate bone cement, used during vertebroplasty, could leak. Such leakage could cause damage to soft tissues and nerves. It is extremely important that the patient is sure that the health care provider has had significant experience performing the vertebroplasty procedure.

Percutaneous kyphoplasty. The health care provider injects bone cement into the space surrounding a fractured vertebra. (Vertebroplasty injects the cement directly into the vertebra.) Kyphoplasty is used to stabilize the spine and return spinal height to as normal as possible. However, a review, published in 2006 by a nonprofit health services research agency, found that the technique does not improve a person's back pain or quality of life. Kyphoplasty should only be done if bed rest, medicines, and physical therapy do not relieve back pain. Those with severe fractures or spinal infections should not have kyphoplasty.

Artificial Disk Replacement. Total disk replacement is an investigative procedure for some patients with severely damaged disks. The technique implants artificial disks (ProDisc, Link, SB Charite) consisting of two metal plates and a soft core. The surgery can be performed using a minimally invasive laparoscopic procedure, which is performed through tiny cuts using miniature tools and viewing devices. A study in 2003 was the first to suggest that it may eventually achieve results that are comparable to standard surgeries for disk herniation. An artificial cushioning device called the prosthetic disk nucleus (PDN) replaces only the inner gel-like core (nucleus pulposus) within the intervertebral space, rather than the entire disk. It is showing promise in early studies.

Radiofrequency Nerve Destruction. Radiofrequencies are being used to destroy nerves involved in the facet joints (or z-joints), which connect the vertebrae. Evidence is still weak on its benefits. A 2003 analysis suggested that it may be beneficial, however, for relief of neck pain and possibly for low back pain caused by problems in the facets joints. Serious infections have been reported with this treatment, however.

Intradiscal Electrothermal Treatment (IDET). Intradiscal electrothermal treatment (IDET) uses electricity to heat a painful disk. Heat is applied for about 15 minutes. Pain may temporarily feel worse, but after healing, the disk shrinks and becomes desensitized to pain. However, healing takes several weeks. While some studies have reported benefit, many consider the evidence to support the use of this procedure weak.

Prognosis

Most people with acute low back pain are back at work within a month and fully recover within a few months. According to one study, about a third of patients with uncomplicated low back pain significantly improved after a week; two-thirds recovered by 7 weeks.

However, studies now suggest that up to 75% of patients suffer at least one recurrence of back pain over the course of a year. After 4 years, fewer than half of patients may be symptom-free. Some doctors are approaching the problem as one that is not necessarily curable and that needs a consistent on-going approach.

Specific conditions can determine the rate of improvement. For example:

Prevention And Self-Care

Most patients should understand that they are likely to improve over the first month after their low back pain begins, often with no treatments.

Exercise, diet, stress, and weight all have a significant influence on back pain. Changing certain lifestyle factors can help reduce, and possibly prevent, backaches.

Smokers are at higher risk for back problems, perhaps because smoking decreases blood circulation. The link may also be due to an unhealthy lifestyle in general. A British study found that young adults who were long-term smokers were nearly twice as likely to develop low back pain as nonsmokers were.

Sedentary Lifestyle. People who do not exercise regularly face an increased risk for low back pain, especially when they perform sudden, stressful activities such as shoveling, digging, or moving heavy items. Although no definitive studies have been done to prove the relationship between lack of exercise and low back pain, some doctors believe that an inactive lifestyle may be to blame in some cases. Lack of exercise leads to the following conditions that may threaten the back:

Improper or Intense Exercise. Improper or excessive exercise may also increase one's chances for back pain.

The way a person moves, stands, or sleeps plays a major role in back pain.

Anyone who engages in heavy lifting should take precautions when lifting and bending.

Spinal curves
There are four natural curves in the spinal column: the cervical, thoracic, lumbar, and sacral curvature. The curves, along with the intervertebral disks, help to absorb and distribute stresses that occur from everyday activities such as walking or from more intense activities such as running and jumping.

Resources

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Review Date: 4/20/2008
Reviewed By: Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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