Tzanck test
Definition
The Tzanck test is a method of testing sores for the herpes simplex virus (which causes cold sores, fever blister, or genital sores), or varicella-zoster virus (which causes chickenpox and "shingles").
Alternative Names
How the Test is Performed
The sore is scraped and the scraping is put on a slide and stained. The health care provider then examines it under a microscope.
How to Prepare for the Test
There is no special preparation necessary.
How the Test Will Feel
When the sore is scraped or rubbed, there may be mild discomfort.
Why the Test is Performed
The test may help diagnose or confirm an infection with one of these two viruses. This test cannot distinguish between these two viruses.
Normal Results
No presence of herpes-infected cells in the scraping is normal.
What Abnormal Results Mean
The results are immediately available. If herpes-infected cells are detected, the patient has been infected with one or the other of the following:
- Herpes simplex (which causes cold sores, fever blister, or genital sores)
- Varicella-zoster virus (which causes chickenpox and "shingles").
Risks
There are no risks with this test.
Considerations
There is a high rate of false-negative results even when the virus is present.
Reviewed By: Kenneth Wener, M.D., Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA. Review provided by VeriMed Healthcare Network.
