Neurofibromatosis 2
Definition
Neurofibromatosis 2 (NF2) is a genetic disorder in which tumors form on the nerves of the brain and spine (the central nervous system).
See also: Neurofibromatosis 1 (NF1)
Alternative Names
NF2; Bilateral acoustic neurofibromatosis; Central bilateral acoustic NF
Causes
NF2 is passed down through families in an autosomal dominant fashion. This means that if one parent has NF2, any child of that parent has a 50-50 chance of having it.
The main risk factor is having a family history of the condition.
Symptoms
Symptoms of NF2 include:
- Balance problems
- Cataracts at a young age
- Changes in vision
- Coffee-colored marks on the skin
- Facial weakness
- Headaches
- Hearing loss
- Ringing and noises in the ears
Exams and Tests
Signs include:
- Brain and spinal tumors
- Hearing-related (acoustic) tumors
- Skin tumors
Tests include:
- Genetic testing
- Medical history
- MRI
- Physical examination
Treatment
Most patients need surgery to remove tumors. Tumors also can be treated with radiation.
Support Groups
For information and support, visit www.nf.org.
Review Date:
10/25/2007
Reviewed By: Chad Haldeman-Englert, M.D., Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
Reviewed By: Chad Haldeman-Englert, M.D., Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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